I tried running 4cm in my Patchmate with bad outcome. First in the set of loops that go in front of my amp (1-4) and then the set of loops that go to amp return (5-8). When i would turn on the 2nd part in the loop my tone would go to shit. But the part of the x pattern in front was fine. Maybe because the Loop 8 has a buffer? A buffer inside a buffer, that's like 16 buffers! But I did it that way because the whole point of having the loop switcher was to get my gate and OD outta my clean channel. But aside from the NS-2 just being in front of my GSP 1101 and amp, it's worked fine. I actually think i wanna just use it in the loop because the gate in the 1101 I've discovered is more than adequate. I would just always leave it one 35-40 and it was never enough. But once I stopped being lazy and delved in and cranked it up to 60 or more on my high gain channels, it's just like an NS-2. Same controls even.