@bostjan I don't experience clipping with the UR22MkII, but the signal does come in hot on the hi-z input even with the knob set at zero. I'm not the only one reporting this, it is a fairly common complaint from UR22MKII users with active pickups (assuming said users don't want to do the obvious and lower their guitar volume). As for the specific reasons why this happens, I think there are a few Youtube videos on the subject. In my case, adding a passive DI box resolves the issue. I don't think anyone here questions the existence of latency (or entropy). I've never encountered "latency issues" with the UR22MkII. @Rawkmann Which MOTU model do you use specifically ? They're also on the list of interfaces I'm looking at. Which OS and DAW do you use ? @ Focusrite 2i2 and 2i4 (2nd gen) users: do you use Windows 10 ? I've heard many complaints about their driver problems for Win10. Are these issues resolved ?